regenerative injectable
Mobile Polynucleotides
in South Wales
From £150
Prices start from £150 for a standard single treatment session. Your personalised treatment plan, including the final cost, will be confirmed during your consultation based on the treatment area, recommended number of sessions, and any package or combination pricing.
Natural-looking skin renewal, guided by clinical expertise.
Polynucleotide treatment is a regenerative injectable treatment designed to support the skin’s natural repair and renewal processes. At Renovo Skin Treatments, we provide mobile polynucleotide treatments across South Wales, including Caerphilly and the surrounding areas. We use polynucleotides to help improve hydration, firmness, elasticity, skin texture and the appearance of fine lines.
Every treatment begins with a comprehensive consultation and skin assessment, allowing us to determine whether polynucleotide treatment is appropriate for your concerns and create a personalised treatment plan.
DOWNTIME
Minimal to moderate. Small raised bumps, redness, swelling, tenderness or bruising may occur following treatment. Raised injection marks usually begin settling within several hours, although swelling or bruising can remain visible for a few days.
treatment plan
A course of two to three treatments, usually spaced several weeks apart, is commonly recommended for the best results. Maintenance appointments may then be advised according to your skin, treatment area and individual response.
Clinically Led
Comprehensive consultation, personalised treatment planning and carefully selected professional polynucleotide products, with the exact product, concentration and treatment plan explained before you proceed.
book a consultation
Every treatment begins with a comprehensive consultation.
We’ll take the time to understand your concerns, assess your suitability for treatment, discuss the most appropriate options and create a personalised treatment plan tailored to your goals.
Not sure whether polynucleotides are right for you?
Polynucleotides are just one of the skin treatments available at The Renovo Clinic. Explore our full range of mobile aesthetic treatments in South Wales or book a consultation to discuss your concerns.
How it works
Polynucleotides are purified nucleotide chains delivered through a series of precise injections into the skin. They help create an environment that supports fibroblast activity, hydration and the skin’s natural repair processes.
Rather than filling lines or altering facial contours, treatment aims to gradually improve the quality, resilience and appearance of the skin itself.
Every patient begins with a thorough consultation and assessment to ensure treatment is appropriate, safe and tailored to their individual concerns and goals.
Benefits
✔ Helps improve hydration, firmness and elasticity
✔ Softens the appearance of fine lines and crepey skin
✔ Supports gradual skin repair and regeneration without adding artificial volume
✔ Particularly suited to delicate areas such as the under-eyes, around the mouth, face and neck
Frequently Asked Questions
Polynucleotides are purified chains of nucleotides, which are components found naturally within DNA. In aesthetic treatments, they are delivered through a series of precise injections to support the skin’s natural repair processes and improve overall skin quality.
Unlike dermal fillers, polynucleotides are not primarily intended to add volume or change facial shape.
Polynucleotide treatment may help improve:
- Fine lines and crepey-looking skin
- Hydration
- Firmness and elasticity
- Uneven or rough texture
- Dull or tired-looking skin
- The quality of delicate skin around the eyes
- General skin resilience and condition
Results develop gradually. The aim is healthier-looking, better-quality skin rather than an immediate or dramatic transformation.
Clinical studies have reported promising improvements in skin texture, elasticity, hydration and wrinkles. However, the available research includes relatively small studies and different products and treatment protocols, so results cannot be guaranteed.
Polynucleotides are injected into the skin, where they are intended to support tissue repair and the environment surrounding skin cells.
They may help support fibroblast activity and the extracellular matrix, contributing to gradual improvements in hydration, elasticity, texture and dermal quality. They do not freeze facial muscles or physically fill lines in the same way as botulinum toxin or dermal filler.
Many professional polynucleotide products are derived from highly purified fragments of fish DNA. The exact source and manufacturing process depend on the brand.
Renovo currently uses VITARAN, which contains highly purified salmon trout DNA fragments and provides 20 mg/ml of polynucleotides. The exact product, concentration and quantity used will be explained before treatment.
“Salmon sperm facial” is an informal phrase sometimes used online, but it is not a helpful or accurate description of the finished medical product.
Professional polynucleotide injectables contain purified and processed DNA fragments. They are manufactured as sterile products for professional use rather than injecting untreated biological material.
Fish-derived polynucleotide products are not vegan.
If avoiding animal-derived ingredients is important to you, please tell us during your consultation. We will always identify the exact product and its source before you decide whether to proceed.
Anyone with a known or suspected fish allergy must tell us before treatment.
Suitability will depend on your allergy history and the instructions for the particular product being considered. Treatment should not proceed until this has been properly assessed.
Polynucleotides are sometimes grouped under the broad term “skin boosters”, but they are not the same as conventional hyaluronic acid skin boosters.
Traditional skin boosters primarily focus on placing hyaluronic acid within the skin to improve hydration and temporary plumping. Polynucleotides are positioned more around skin repair, resilience and gradual improvement in tissue quality.
Neither category is automatically better. The most appropriate treatment depends on your skin, concerns and desired outcome.
No. Polynucleotides are not used to create the structural volume or facial contouring associated with dermal fillers.
They are intended to improve the condition and quality of the skin itself. They will not substantially enlarge the lips, project the cheeks, reshape the jawline or replace significant volume loss.
Polynucleotide treatment is not permanent, and there is no single duration that applies to every patient or product.
How long the improvement remains visible will depend on your age, skin condition, sun exposure, smoking, skincare, lifestyle and the initial treatment course completed.
Maintenance appointments may be recommended once improvements begin to reduce. Your skin will gradually return towards its previous condition if treatment is not repeated.
A single treatment may provide some improvement, but polynucleotides are generally better viewed as a course-based treatment.
Skin repair and remodelling take time. A structured course gives the skin repeated stimulation and allows your response to be reviewed between appointments.
The recommended course and total cost will always be explained before you commit to treatment.
You will receive personalised aftercare advice. You will usually be advised to avoid:
- Touching, pressing or massaging the treated area unnecessarily
- Applying makeup immediately after treatment
- Strenuous exercise for approximately 24 hours
- Saunas, steam rooms and excessive heat
- Swimming until the injection sites have settled
- Strong exfoliating acids and retinoids until the skin has recovered
- Alcohol where swelling or bruising is a concern
- Excessive sun exposure
A gentle skincare routine and broad-spectrum SPF50 should be used as advised.
It is generally best to avoid applying makeup immediately after treatment because the injection sites need time to close and settle.
You will be advised when it is appropriate to resume makeup, based on the area treated and how your skin responds.
NCTF 135 HA and polynucleotides are different injectable treatments.
NCTF 135 HA combines non-crosslinked hyaluronic acid with amino acids, vitamins, minerals, coenzymes and other supporting ingredients. It is particularly suited to dehydration, dullness, superficial fine lines and general skin revitalisation.
Polynucleotides contain purified nucleotide chains and are more strongly positioned around gradual skin repair, elasticity, resilience and tissue quality.
There is some overlap between the concerns they may address. Your consultation will help determine which approach is more appropriate.
No. Polynucleotide products can differ considerably in:
- Polynucleotide concentration
- Syringe volume
- Molecular characteristics
- Purification process
- Biological source
- Intended treatment area
- Supporting ingredients
- Regulatory documentation
- Manufacturer protocols
- Clinical evidence
- Price
This is why Renovo does not treat “polynucleotides” as though every vial is interchangeable.
There is a growing body of research suggesting that injectable polynucleotides may improve measures such as skin texture, elasticity, hydration and wrinkle appearance.
However, the current evidence base is not perfect. Reviews have identified small patient numbers, variation in products and injection protocols, and studies of low to moderate quality. Polynucleotides should therefore be described as a promising skin-quality treatment rather than a guaranteed solution.
Depending on the product and formulation selected, polynucleotides may be used on areas including:
- The under-eyes and eye contour
- The face
- Fine lines around the mouth
- The neck
- The décolletage
- The hands
- Other areas of thin, crepey or damaged-looking skin
Different formulations may be designed for different anatomical areas. Renovo will confirm the exact product and treatment area following assessment. VITARAN’s professional range includes formulations intended for the periorbital area, face, neck and décolletage.
Yes. Specific polynucleotide formulations can be used to improve fine, crepey or dehydrated-looking skin around the eyes.
Treatment may help the area appear smoother, firmer and fresher. However, it cannot correct every cause of dark circles, hollowing or under-eye bags.
Dark circles can be caused by pigmentation, visible blood vessels, shadowing, volume loss or facial anatomy. Polynucleotides will therefore be more suitable for some under-eye concerns than others.
Polynucleotides are not a direct treatment for prominent fat pads or significant under-eye bags.
They may improve the quality of the overlying skin, but they cannot remove or reposition fat. Temporary swelling can also occur after treatment, particularly around the eyes.
Your under-eye anatomy must be assessed before treatment so that realistic expectations can be discussed.
Polynucleotides may be used to improve thin, crepey or finely lined skin around the mouth.
They will not create the structural support or volume associated with dermal filler, and they cannot completely remove deeper lines caused by significant volume loss, repeated movement or sun damage. They may form part of a wider treatment plan where appropriate.
Your appointment begins with a consultation and assessment of your skin, medical history and treatment goals.
The skin is then cleansed and prepared. Small quantities of the selected polynucleotide product are delivered through a series of precise injections across the treatment area.
These injections often create small raised bumps, known as micropapules. These are expected and usually begin to flatten as the product disperses.
Polynucleotide injections can feel uncomfortable. Patients commonly describe a series of pinpricks, pressure or a brief stinging sensation.
The level of discomfort varies according to the treatment area, injection technique and individual sensitivity. The under-eyes and areas around the mouth can be more sensitive than other parts of the face.
Appropriate comfort measures will be discussed before treatment.
Downtime is usually minimal to moderate, although the skin may not look completely unchanged immediately afterwards.
Temporary effects can include:
- Small raised injection bumps
- Redness
- Swelling
- Tenderness
- Pinpoint bleeding
- Itching or sensitivity
- Bruising
Micropapules often settle within several hours to a few days. Swelling around the eyes can occasionally remain visible for longer, while bruising may take several days to resolve.
You should avoid arranging treatment immediately before an important event.
Polynucleotides are not intended to produce an instant transformation.
Some people notice improved hydration or freshness following their initial treatment. Changes in texture, elasticity and fine lines are usually expected to develop more gradually over the following weeks and throughout a treatment course.
Results vary between patients and depend on factors including age, skin condition, lifestyle, treatment area, product used and the number of appointments completed.
A course of treatment is usually recommended rather than a single appointment.
Renovo commonly plans an initial course of approximately three treatments, spaced several weeks apart, followed by a review. The exact number and timing will be based on the product protocol, treatment area, your skin and your response to treatment.
Some published polynucleotide protocols use between two and four sessions, but substantial variation exists between products and clinical studies.
Polynucleotides may be considered for adults experiencing:
- Fine lines
- Crepey or fragile-looking skin
- Dehydration
- Reduced firmness or elasticity
- Dullness
- Uneven texture
- Early signs of ageing
- Tired-looking under-eye skin
- A general decline in skin quality
A consultation is necessary because the same concern can have several different causes. Another treatment may sometimes be more suitable.
Treatment may not be appropriate where there is:
- Pregnancy or breastfeeding
- Active infection or inflammation in the treatment area
- An active cold sore outbreak near the proposed treatment area
- A relevant allergy or sensitivity
- A significant bleeding disorder
- Poorly controlled medical conditions
- A history that increases the risk of an adverse reaction
- Recent treatment that has not fully healed
This is not an exhaustive list. Your medical history, medication, allergies and previous aesthetic treatments must be discussed during consultation.
Polynucleotides may form part of a wider treatment plan alongside procedures such as NCTF 135 HA, hyaluronic acid skin boosters, microneedling, chemical peels or anti-wrinkle treatment.
These treatments will not necessarily be performed during the same appointment. Appropriate spacing allows the skin to recover and makes it easier to assess the response to each procedure.
Renovo will recommend a staged plan based on your concerns rather than combining treatments without a clear clinical reason.
Renovo currently uses VITARAN, a professional polynucleotide injectable containing 20 mg/ml of polynucleotides derived from highly purified salmon trout DNA fragments.
Our product formulary may develop as new evidence and formulations become available. The exact product, concentration, quantity, rationale and price will always be explained and agreed before treatment.
We will never quietly substitute a cheaper or different product.
The Renovo Clinic provides mobile, clinician-led polynucleotide treatments in South Wales.
Every treatment begins with a comprehensive consultation and assessment. We will explain what the treatment can realistically achieve, which product is being recommended, its concentration, why it has been selected and whether another option may be more suitable.
Our approach focuses on gradual, natural-looking improvements in skin quality rather than artificial volume or trend-led treatment.
Renovo Skin Treatments is a mobile aesthetics service providing treatments in the comfort of your own home across South Wales, including Blaenau Gwent, Caerphilly, Merthyr Tydfil, Blackwood, Cwmbran, Risca and Abergavenny. We bring everything needed for your appointment, including a portable treatment bed, clinical equipment and lighting. There’s no additional travel charge within our advertised coverage area. If you’re unsure whether we cover your location, just get in touch.